Which cell lineage is affected in XID mice?

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Multiple Choice

Which cell lineage is affected in XID mice?

Explanation:
In XID mice, the defect hits the B cell lineage. The mutation impairs Bruton's tyrosine kinase (BTK), a crucial signaling molecule for B cell development. Without BTK, B cell signaling through the pre-B and B cell receptors cannot proceed, so B cells fail to mature past the early developmental stages and are depleted, leading to very low mature B cells and antibodies. Other lineages like T cells, NK/null cells, and dendritic cells develop normally in numbers, so the primary impact is on B cells.

In XID mice, the defect hits the B cell lineage. The mutation impairs Bruton's tyrosine kinase (BTK), a crucial signaling molecule for B cell development. Without BTK, B cell signaling through the pre-B and B cell receptors cannot proceed, so B cells fail to mature past the early developmental stages and are depleted, leading to very low mature B cells and antibodies. Other lineages like T cells, NK/null cells, and dendritic cells develop normally in numbers, so the primary impact is on B cells.

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