What is the most common side effect of NSAIDs?

• A. Depression of respiration
• B. Gastrointestinal irritation
• C. Drop in blood pressure
• D. Burning sensation at the site of injection

Answer: (B)

NSAIDs reduce prostaglandin production by inhibiting COX enzymes, and those prostaglandins normally help protect the stomach lining. When this protection is diminished, the gastric mucosa becomes irritated more easily, leading to dyspepsia, gastritis, and even ulcers. That widespread effect on the GI tract makes gastrointestinal irritation the most common side effect of NSAIDs.

Other listed effects aren’t typical for NSAIDs as a class. They don’t usually cause respiratory depression or a drop in blood pressure as common side effects, and a burning sensation at an injection site isn’t a characteristic feature of NSAID use.