What is the first antibody which is detected in response to an initial exposure to an antigen?

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Multiple Choice

What is the first antibody which is detected in response to an initial exposure to an antigen?

Explanation:
When the body first encounters an antigen, it responds with IgM antibodies. Naive B cells quickly become plasmablasts that secrete IgM before any class-switching occurs. IgM is a pentamer, giving it high avidity and strong ability to activate complement, which provides an early defense while the more refined, high-affinity responses are developing. Over time, B cells undergo class-switch recombination and produce other isotypes such as IgG, IgA, or IgE, so those become more prominent later. So the initial, first detectable antibody in a primary exposure is IgM.

When the body first encounters an antigen, it responds with IgM antibodies. Naive B cells quickly become plasmablasts that secrete IgM before any class-switching occurs. IgM is a pentamer, giving it high avidity and strong ability to activate complement, which provides an early defense while the more refined, high-affinity responses are developing. Over time, B cells undergo class-switch recombination and produce other isotypes such as IgG, IgA, or IgE, so those become more prominent later. So the initial, first detectable antibody in a primary exposure is IgM.

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