What is another term for reverse tolerance to a drug?

• A. Side effect
• B. Potentiation
• C. Sensitization
• D. Antagonism

Answer: (C)

Reverse tolerance, also called sensitization, occurs when repeated exposure to a drug makes the body respond more strongly to each dose, so smaller amounts produce larger effects over time. This is the opposite of tolerance, where continued use reduces responsiveness and higher doses are needed. Sensitization can arise from neural adaptations that heighten receptor sensitivity or signaling. That’s why sensitization is the term that best fits reverse tolerance. The other options describe different ideas: a side effect is an undesirable reaction, potentiation is when one drug boosts the effect of another, and antagonism is when a substance blocks or reduces the drug’s effect.