Ketamine is commonly used in conjunction with which type of drug in large animals?

• A. Anticholinergics
• B. Antipsychotics
• C. Antihistamines
• D. Antibiotics

Answer: (A)

Ketamine is commonly paired with an anticholinergic in large animals to manage airway secretions and cardiovascular stability during anesthesia. Ketamine can increase salivation and, in some cases, provoke reflex changes in heart rate. Anticholinergic drugs, such as atropine or glycopyrrolate, block acetylcholine at muscarinic receptors, which reduces secretions (saliva and bronchial mucus) and helps prevent vagally mediated bradycardia. This combination makes induction and handling of the airway smoother and safer, especially in horses and cattle. The other drug types listed don’t provide this immediate action for secretion control and heart-rate support during induction.