Ivermectin use requires caution in which group of dogs?

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Multiple Choice

Ivermectin use requires caution in which group of dogs?

Explanation:
Ivermectin safety hinges on how a dog’s brain protects itself from the drug. In most dogs, a transporter protein at the blood–brain barrier, produced by the MDR1 (ABCB1) gene, pumps ivermectin out of the brain, keeping brain exposure low. When a dog carries the MDR1 mutation, that transporter doesn’t work well, so ivermectin can accumulate in the CNS and cause neurologic toxicity—ataxia, tremors, dilated pupils, weakness, or even loss of consciousness. Sight hound breeds are emphasized for caution because many lines carry this mutation, or breeders have historically noted sensitivity in this group. So, in practice, if you’re considering ivermectin in sight hounds, you should test for MDR1 status when possible or opt for an alternative parasite preventive and closely monitor for any signs of CNS effects.

Ivermectin safety hinges on how a dog’s brain protects itself from the drug. In most dogs, a transporter protein at the blood–brain barrier, produced by the MDR1 (ABCB1) gene, pumps ivermectin out of the brain, keeping brain exposure low. When a dog carries the MDR1 mutation, that transporter doesn’t work well, so ivermectin can accumulate in the CNS and cause neurologic toxicity—ataxia, tremors, dilated pupils, weakness, or even loss of consciousness.

Sight hound breeds are emphasized for caution because many lines carry this mutation, or breeders have historically noted sensitivity in this group. So, in practice, if you’re considering ivermectin in sight hounds, you should test for MDR1 status when possible or opt for an alternative parasite preventive and closely monitor for any signs of CNS effects.

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